Advanced DUTCH Check

This comprehensive assessment of oestrogen levels and metabolism, measures key oestrogen forms (oestradiol, oestrone, and oestriol) along with their breakdown pathways.

Oestradiol

The primary form of oestrogen in premenopausal women, important for reproductive health and bone density.

Oestrone

A weaker form of oestrogen, often elevated in postmenopausal women and can be converted to oestradiol.

Oestriol

A weaker oestrogen metabolite, typically highest during pregnancy.

Oestrogen Quotient

A ratio that helps assess oestrogen balance and cancer risk.

2-OH Oestradiol

A beneficial oestrogen metabolite that may protect against cancer.

2-OH Oestrone

A beneficial oestrogen metabolite associated with lower cancer risk.

4-OH Oestradiol

A potentially harmful oestrogen metabolite that may increase cancer risk.

4-OH Oestrone

A potentially harmful oestrogen metabolite associated with increased cancer risk.

16α-OH Oestrone

A potentially harmful oestrogen metabolite that may increase breast cancer risk.

2-OH (E1 + E2)/16-α-OH E1

A ratio that helps assess oestrogen metabolism balance and cancer risk.

2-MeO Oestradiol

A protective oestrogen metabolite that helps clear harmful oestrogens.

2-MeO Oestrone

A protective oestrogen metabolite that supports healthy oestrogen clearance.

2-MeO E1/2-OH E1

A ratio indicating the efficiency of protective oestrogen metabolism pathways.

4-MeO Oestradiol

A metabolite that helps clear potentially harmful 4-OH oestrogens.

4-MeO Oestrone

A metabolite that supports the clearance of potentially harmful 4-OH oestrogens.

4-MeO E1/4-OH E1

A ratio indicating the efficiency of clearing potentially harmful 4-OH oestrogens.

4-MeO E2/4-OH E2

A ratio showing the balance between harmful and protective 4-OH oestrogen metabolites.

This test evaluates progesterone metabolism, providing insights into overall hormone balance, adrenal health, and the body's ability to convert progesterone effectively.

Pregnanediol

The main metabolite of progesterone, indicating overall progesterone production and metabolism.

Allopregnanolone

A neuroactive progesterone metabolite that supports mood, sleep, and stress resilience.

Allopregnanediol

A progesterone metabolite that helps assess overall progesterone metabolism.

3α-Dihydroprogesterone

A progesterone metabolite involved in the conversion to allopregnanolone.

20α-Dihydroprogesterone

A progesterone metabolite that helps assess progesterone breakdown pathways.

Deoxycorticosterone

A precursor to both progesterone and cortisol, indicating adrenal function.

Corticosterone

A steroid hormone that helps assess adrenal function and stress response.

Pgdiol/E2

A ratio of progesterone to oestrogen metabolites, indicating hormone balance.

This test measures primary androgens, including DHEA, testosterone, and their metabolites, providing a comprehensive view of androgen production and metabolism.

DHEA

A precursor hormone that converts to testosterone and oestrogen, important for energy and vitality.

Androstenedione

A precursor to both testosterone and oestrogen, indicating overall androgen production.

Androsterone

A testosterone metabolite that helps assess androgen metabolism and clearance.

Etiocholanolone

A testosterone metabolite that provides insights into androgen breakdown pathways.

Testosterone

The primary male sex hormone, also important in women for energy, muscle mass, and libido.

Epi-Testosterone

An isomer of testosterone that helps assess testosterone metabolism.

T/Epi-T

A ratio that helps detect testosterone use and assess natural testosterone production.

5α-DHT

Dihydrotestosterone, a potent androgen metabolite important for male characteristics and hair growth.

5α,3α-Androstanediol

A metabolite of DHT that helps assess androgen activity and metabolism.

This test measures urinary melatonin levels throughout the day, providing insight into your body's natural sleep-wake cycle and overall circadian rhythm function.

Melatonin - 1st Morning

Measures melatonin levels in the first morning urine, reflecting overnight melatonin production and sleep quality.

Melatonin - 2nd Morning

Assesses melatonin levels as you wake, indicating the natural decline of melatonin with daylight.

Melatonin - Evening

Measures evening melatonin levels, indicating the body's preparation for sleep and circadian rhythm function.

Melatonin - Night

Assesses nighttime melatonin production, crucial for deep, restorative sleep and circadian rhythm regulation.

This test assesses exposure to common endocrine disruptors, including heavy metals, plastics, and industrial chemicals, which can interfere with hormone function.

Bisphenol A (BPA)

A common plastic chemical that can mimic oestrogen, potentially disrupting hormone balance and fertility.

Polyfluoroalkyl Substances (PFAS)

A group of industrial chemicals linked to hormone disruption, immune dysfunction, and cancer risk.

Perfluorooctanoic Acid (PFOA)

A persistent environmental toxin associated with thyroid disruption, immune dysfunction, and reproductive issues.

Perfluorooctane Sulphonic Acid (PFOS)

Another persistent pollutant found in non-stick and waterproof products, linked to hormone disruption and immune stress.

Aluminium

A common metal toxin that can accumulate in the brain, bones, and lungs, potentially contributing to neurotoxicity and bone weakness.

Arsenic

A heavy metal that can interfere with cellular energy production and increase the risk of cancer, heart disease, and diabetes.

Cadmium

A toxic metal that can affect kidney function, bone health, and respiratory function, often from smoking or industrial exposure.

Lead

A highly toxic heavy metal known for its impact on brain development, nervous system function, and cardiovascular health.

Mercury

A potent neurotoxin that can impair brain function, immune health, and detoxification pathways.

Nickel

A common industrial metal that can cause skin irritation, respiratory issues, and allergic reactions if levels are too high.

This panel includes a range of nutritional organic acids that reflect vitamin status, neurotransmitter metabolism, and cellular energy production.

Xanthurenic Acid

A marker of vitamin B6 deficiency and tryptophan metabolism, associated with inflammation and immune dysfunction.

β-Hydroxyisovaleric Acid

A byproduct of leucine metabolism, often elevated in biotin deficiency or protein breakdown.

Methylmalonic Acid

An indicator of vitamin B12 status, elevated when B12 is deficient or methylation is impaired.

Homovanillic Acid (HVA)

A dopamine metabolite reflecting dopamine turnover and adrenal function.

Vanillylmandelic Acid (VMA)

A norepinephrine and epinephrine metabolite, reflecting sympathetic nervous system activity and adrenal stress.

Kynurenic Acid

A tryptophan metabolite that reflects immune activation and neuroinflammation.

Quinolinic Acid

A neurotoxic tryptophan metabolite linked to inflammation, neurodegeneration, and mood disorders.

8-OH-deoxyguanosine

A marker of DNA oxidative damage, reflecting cellular stress and free radical exposure.

Pyroglutamic Acid

A marker of glutathione status, reflecting the body's detox capacity and antioxidant defenses.

Indoleacetic Acid

A serotonin metabolite reflecting gut serotonin production and intestinal health.

Urinary free diurnal cortisol testing provides a detailed view of adrenal function, stress response, and circadian rhythm, revealing patterns that impact energy, sleep, and long-term resilience.

Free Cortisol - 1st Morning

Measures cortisol at its natural peak, reflecting the body's ability to wake and respond to daily demands.

Free Cortisol - 2nd Morning

Assesses cortisol levels as they begin to decline, indicating adrenal function during the active part of the day.

Free Cortisol - Evening

Measures cortisol levels later in the day, when they should be declining to allow for rest and recovery.

Free Cortisol - Night

Assesses nighttime cortisol levels, which should be low to support restful sleep and melatonin production.

Urinary glucocorticoid testing assesses adrenal health, stress response, and metabolic resilience, providing insights into energy levels, inflammation, and overall hormonal balance.

Total Cortisol

The sum of all cortisol metabolites, providing an overall assessment of adrenal function and stress hormone production.

Total Cortisone

The inactive form of cortisol, indicating how efficiently the body regulates active stress hormones.

Cortisol/Cortisone

A ratio that helps assess the balance between active and inactive cortisol, indicating stress hormone regulation.

Tetrahydrocortisol (THF)

A major cortisol metabolite that helps assess overall cortisol production and clearance.

Tetrahydrocortisone (THE)

A major cortisone metabolite that helps assess cortisol inactivation and clearance.

Metabolised Cortisol (THF+THE)

The sum of THF and THE, representing the total metabolised glucocorticoids and overall adrenal function.

11β-HSD Index (THF/THE)

Measures the balance between active cortisol and its inactive form cortisone, reflecting how efficiently your body converts and regulates stress hormones.

Urinary free diurnal cortisone testing reveals how your body regulates stress and recovery, providing insights into adrenal function, daily energy patterns, and long-term hormone balance.

Free Cortisone - 1st Morning

Measures inactive cortisone levels at their natural peak, reflecting overnight adrenal output and the body's ability to clear active cortisol.

Free Cortisone - 2nd Morning

Reflects cortisone levels as they decline from the morning peak, indicating adrenal function and cortisol metabolism during the active part of the day.

Free Cortisone - Afternoon

Measures cortisone levels later in the day, reflecting the body's ability to sustain energy and regulate stress as cortisol naturally declines.

Free Cortisone - Evening

Assesses cortisone levels at the end of the day, when they should be lowest to allow for melatonin production and restful sleep.

Urinary creatinine testing provides insights into kidney function, hydration status, and overall muscle health, helping to standardise hormone metabolism measurements.

Creatinine (pooled)

Overall creatinine levels, used to standardise hormone measurements and assess kidney function.

Creatinine - 1st Morning

Reflects muscle breakdown and kidney function during the active part of the day.

Creatinine - Midday

Measures muscle and kidney clearance later in the day, reflecting activity level and hydration status.

Creatinine - Afternoon

Indicates muscle metabolism and renal function during the winding down phase of the day.

Creatinine - Evening

Assesses muscle metabolism and kidney function at the end of the day.