Genetic Methylation Check

Your methylation profile describes your body's ability to regulate methylation, a vital process affecting DNA repair, detoxification, neurotransmitter...

This genetic methylation test includes the essential MTHFR, COMT, MTRR, MTR, MTHFD1, PEMT and CBS methylation genes.

MTHFR C677T

MTHFR helps our bodies use folate effectively, but certain genetic differences, like C677T and A1298C, can slow it down. If someone has two copies of C677T or a mix of C677T and A1298C, it slows MTHFR even more, making it harder to convert homocysteine. This could lead to higher homocysteine levels, which might increase the risk of heart problems.

MTHFR A1298C

MTHFR helps our bodies use folate effectively, but certain genetic differences, like C677T and A1298C, can slow it down. If someone has two copies of C677T or a mix of C677T and A1298C, it slows MTHFR even more, making it harder to convert homocysteine. This could lead to higher homocysteine levels, which might increase the risk of heart problems.

MTR A2756G

MTR and MTRR use folate and vitamin B12 to produce a crucial substance called methionine. If someone has two identical mutations in MTRR, or mutations in both MTR and MTRR, it can greatly reduce methionine production, potentially leading to higher levels of homocysteine in the blood and raising the risk of conditions like coronary artery disease.

MTRR A66G

MTR and MTRR use folate and vitamin B12 to produce a crucial substance called methionine. If someone has two identical mutations in MTRR, or mutations in both MTR and MTRR, it can greatly reduce methionine production, potentially leading to higher levels of homocysteine in the blood and raising the risk of conditions like coronary artery disease.

MTHFD1 G1958A

MTHFD1 helps convert one form of folate into another form that is critical for making DNA and RNA, as well as for providing methyl groups for important cellular processes like methylation. Mutations in MTHFD1 result in lower levels of active folate, which is a key input for downstream biological pathways.

CBS A13637G

The CBS gene helps turn homocysteine into important substances for our body, like proteins and antioxidants that fight cell damage. Some genetic mutations, like the A13637G variant, can weaken this process, potentially raising homocysteine levels and causing cardiovascular issues.

PEMT M175V

The PEMT M175V mutation is associated with having lower choline production in the liver. Choline is essential for a neurotransmitter called acetylcholine, which helps send messages through to various organs like the lungs, heart, and brain. If you don't get enough choline, it could affect memory and sleep, as well as how your organs work.

PEMT C744G

The PEMT C744G mutation is associated with having lower choline production in the liver. Choline is essential for a neurotransmitter called acetylcholine, which helps send messages through to various organs like the lungs, heart, and brain. If you don't get enough choline, it could affect memory and sleep, as well as how your organs work.

COMT V158M

The V158M mutation in COMT can change how quickly your body breaks down dopamine, adrenaline, and noradrenaline, which affects mood, thinking, and stress. This contributes to health outcomes including cognitive performance, susceptibility to psychiatric disorders, and stress-related conditions.

AHCY C112T

The AHCY gene is involved in a process called the methionine cycle, which plays an important role in the metabolism of the amino acid methionine.

AHCY G274A

The AHCY gene is involved in a process called the methionine cycle, which plays an important role in the metabolism of the amino acid methionine.

Methylation plays a key role in cardiovascular health by regulating processes essential for heart and blood vessel function.

Methylation is essential for brain health through its effects on neurotransmitter production, brain cell repair, and inflammation regulation.

Methylation is essential for balancing neurotransmitters like dopamine, serotonin, and noradrenaline, which regulate mood, memory, and focus.

Sleep onset, maintenance and quality can be influenced by genetic variations in the PEMT and COMT genes.

Methylation supports gut health by regulating the genes involved in digestion, inflammation, and gut barrier function.

Methylation is crucial for energy production as it influences the function of mitochondria, the cell's powerhouses.

Methylation plays a crucial role in regulating immune response and cellular repair.

Hormone & Reproductive Health refers to the balance of hormones that regulate the reproductive system, influencing fertility, menstrual cycles, and overall reproductive function.